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  ICAT: a novel algorithm to robustly identify cell states following perturbations in single cell transcriptomes 

  Hawkins, Dakota Y.; Zuch, Daniel T.; Huth, James; Rodriguez-Sastre, Nahomie; McCutcheon, Kelley R.; Glick, Abigail; Lion, Alexandra T.; Thomas, Christopher F.; Descoteaux, Abigail E.; Johnson, W. Evan; Bradham, Cynthia A. (2022-05-29)
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  Associations of accelerometer-measured physical activity and sedentary time with chronic kidney disease: The Framingham Heart Study 

  Lee, Joowon; Walker, Maura E.; Gabriel, Kelley P.; Vasan, Ramachandran S.; Xanthakis, Vanessa (2020)

  BACKGROUND: Few studies examined the individual and conjoint associations of accelerometer-measured physical activity (PA) and sedentary times with the prevalence of chronic kidney disease (CKD) among older adults. METHODS: ...
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  Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Zamboni, Robert J.; Kodukula, Krishna; Chen, Xiaohong (Mary Ann Liebert, Inc., 2020)

  In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ...
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  Epigenetic treatment of dermatologic disorders 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. (Wiley, 2019-09)

  Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ...
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  Epigenetic treatment of persistent viral infections 

  Moos, Walter H.; Pinkert, Carl A.; Irwin, Michael H.; Faller, Douglas V.; Kodukula, Krishna; Glavas, Ioannis P.; Steliou, Kosta (Wiley, 2017-02-01)

  Approximately 2,500 years ago, Hippocrates used the word herpes as a medical term to describe lesions that appeared to creep or crawl on the skin, advocating heat as a possible treatment. During the last 50 years, ...
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  Epigenetic treatment of neuropsychiatric disorders: autism and schizophrenia 

  Moos, Walter H.; Maneta, Eleni; Pinkert, Carl A.; Irwin, Michael H.; Hoffman, Michelle E.; Faller, Douglas V.; Steliou, Kosta (John Wiley & Sons, Inc., 2016-03-01)

  Neuropsychiatric disorders are a heterogeneous group of conditions that often share underlying mitochondrial dysfunction and biological pathways implicated in their pathogenesis, progression, and treatment. To date, these ...
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  Epigenetic treatment of neurodegenerative disorders: Alzheimer and Parkinson diseases 

  Irwin, Michael H.; Moos, Walter H.; Faller, Douglas V.; Steliou, Kosta; Pinkert, Carl A. (Wiley-Blackwell, 2016-05-01)

  In this review we expand our discussion of epigenetic-driven methods for treating neurodegenerative disorders associated with mitochondrial dysfunction, focusing on carnitinoid antioxidant-histone deacetylase inhibitors ...
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  Butyrate histone deacetylase inhibitors. 

  Steliou, Kosta; Boosalis, Michael S.; Perrine, Susan P.; Sangerman, José; Faller, Douglas V. (2012-08)

  In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting ...
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  Low cost extraction and isothermal amplification of DNA for infectious diarrhea diagnosis 

  Huang, Shichu; Do, Jaephil; Mahalanabis, Madhumita; Fan, Andy; Zhao, Lei; Jepeal, Lisa; Singh, Satish K.; Klapperich, Catherine M. (Public Library of Science, 2013-03-28)

  In order to counter the common perception that molecular diagnostics are too complicated to work in low resource settings, we have performed a difficult sample preparation and DNA amplification protocol using instrumentation ...
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  LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages. 

  Bushell, Kristen N.; Leeman, Susan E.; Gillespie, Earl; Gower, Adam C.; Reed, Karen L.; Stucchi, Arthur F.; Becker, James M.; Amar, Salomon (2011)

  Dysregulation of TNF-α in lamina propria macrophages (LPM) is a feature of inflammatory bowel diseases (IBD). LPS-Induced-TNF-Alpha-Factor (LITAF) is a transcription factor that mediates TNF-α expression. To determine ...

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