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  Assessment of binge-like eating of unsweetened vs. sweetened chow pellets in BALB/c substrains 

  Sena, Katherine D.; Beierle, Jacob A.; Richardson, Kayla T.; Kantak, Kathleen M.; Bryant, Camron D. (Frontiers Media SA, 2022)

  Binge eating disorder (BED) is defined as chronic episodes of consuming large amounts of food in less than 2 h. Binge eating disorder poses a serious public health problem, as it increases the risk of obesity, type II ...
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  Spontaneously hypertensive rat substrains show differences in model traits for addiction risk and cocaine self-administration: implications for a novel rat reduced complexity cross 

  Kantak, Kathleen M.; Stots, Carissa; Mathieson, Elon; Bryant, Camron D. (Elsevier BV, 2021-08-06)

  Forward genetic mapping of F2 crosses between closely related substrains of inbred rodents - referred to as a reduced complexity cross (RCC) - is a relatively new strategy for accelerating the pace of gene discovery for ...
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  Probing the neural circuitry targets of neurotoxicants in vivo through high density silicon probe brain implants 

  Ratner, Marcia; Farb, David (Frontiers, 2022-04-22)

  Adverse effects of drugs on the human nervous system are rarely possible to anticipate based on preclinical neurotoxicity data, thus propagating the centuries long single most important obstacle to drug discovery and ...
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  UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response 

  Huiting, L.N.; Samaha, Y.; Zhang, Guanglan; Roderick, J.E.; Li, B.; Anderson, N.M.; Wang, Y.W.; Wang, L.; Laroche, F.J.F.; Choi, J.W.; Liu, C.T.; Kelliher, M.A.; Feng, Hui (Nature Publishing Group, 2018-04-25)

  Despite the pivotal role of MYC in tumorigenesis, the mechanisms by which it promotes cancer aggressiveness remain incompletely understood. Here, we show that MYC transcriptionally upregulates the ubiquitin fusion degradation ...
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  Signaling Pathways Required for Macrophage Scavenger Receptor-Mediated Phagocytosis: Analysis by Scanning Cytometry 

  Sulahian, Timothy H; Imrich, Amy; DeLoid, Glen; Winkler, Aaron R; Kobzik, Lester (BioMed Central, 2008-8-7)

  BACKGROUND. Scavenger receptors are important components of the innate immune system in the lung, allowing alveolar macrophages to bind and phagocytose numerous unopsonized targets. Mice with genetic deletions of scavenger ...
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  Pharmacological Properties of DOV 315,090, an Ocinaplon Metabolite 

  Berezhnoy, Dmytro; Gravielle, Maria C.; Downing, Scott; Kostakis, Emmanuel; Basile, Anthony S.; Skolnick, Phil; Gibbs, Terrell T.; Farb, David H. (BioMed Central, 2008-6-13)

  BACKGROUND. Compounds targeting the benzodiazepine binding site of the GABAA-R are widely prescribed for the treatment of anxiety disorders, epilepsy, and insomnia as well as for pre-anesthetic sedation and muscle relaxation. ...
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  Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy 

  Ma, Qiangzhong; Wang, Yawen; Lo, Agnes Shuk-Yee; Gomes, Erica M.; Junghans, Richard P. (Hindawi Publishing Corporation, 2010-6-30)

  The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had important effects on the process of expansion of T cells in vitro. ...
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  Quantitative Observations of Fever and Its Treatment before the Advent of Short Clinical Thermometers. 

  Estes, J. W. (1991-04)
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  Forebrain Overexpression of CaMKII Abolishes Cingulate Long Term Depression and Reduces Mechanical Allodynia and Thermal Hyperalgesia 

  Wei, Feng; Wang, Guo-Du; Zhang, Chao; Shokat, Kevan M.; Wang, Huimin; Tsien, Joe Z.; Liauw, Jason; Zhuo, Min (BioMed Central, 2006-6-15)

  Activity-dependent synaptic plasticity is known to be important in learning and memory, persistent pain and drug addiction. Glutamate NMDA receptor activation stimulates several protein kinases, which then trigger biochemical ...
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  Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis 

  Li, Nien-Chen; Lee, Austin; Whitmer, Rachel A.; Kivipelto, Miia; Lawler, Elizabeth; Kazis, Lewis E.; Wolozin, Benjamin (BMJ Publishing Group Ltd., 2010-1-12)

  Objective: To investigate whether angiotensin receptor blockers protect against Alzheimer's disease and dementia or reduce the progression of both diseases. Design Prospective cohort analysis. Setting Administrative database ...

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