Pulmonary Center
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An Integration of Complementary Strategies for Gene-Expression Analysis to Reveal Novel Therapeutic Opportunities for Breast Cancer
(BioMed Central, 2009-7-28)INTRODUCTION. Perhaps the major challenge in developing more effective therapeutic strategies for the treatment of breast cancer patients is confronting the heterogeneity of the disease, recognizing that breast cancer is ... -
Growth Factors in Lung Development and Disease: Friends or Foe?
(BioMed Central, 2001-10-9)Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell ... -
Orally Available Mn Porphyrins with Superoxide Dismutase and Catalase Activities
(Springer-Verlag, 2009-6-6)Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious ... -
RNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus Diversification
(Public Library of Science, 2009-7-3)West Nile virus (WNV) exists in nature as a genetically diverse population of competing genomes. This high genetic diversity and concomitant adaptive plasticity has facilitated the rapid adaptation of WNV to North American ... -
Production of IL-16 Correlates with CD4+ Th1 Inflammation and Phosphorylation of Axonal Cytoskeleton in Multiple Sclerosis Lesions
(BioMed Central, 2006-5-26)BACKGROUND Multiple sclerosis (MS) is a central nervous system-specific autoimmune, demyelinating and neurodegenerative disease. Infiltration of lesions by autoaggressive, myelin-specific CD4+Th1 cells correlates with ... -
Role of Free Radicals in the Pathogenesis of Acute Chest Syndrome in Sickle Cell Disease
(BioMed Central, 2001-7-13)Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cells (WBCs) ... -
Development and Prospective Validation of a Model for Predicting Weaning in Chronic Ventilator Dependent Patients
(BioMed Central, 2003-11-13)BACKGROUND. Approximately ten percent of patients placed on mechanical ventilation during acute illness will require long-term ventilator support. Unfortunately, despite rehabilitation, some will never be liberated from ... -
On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies
(Public Library of Science, 2009-11-26)For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, ... -
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) Is related to a diminished CD69 and TGFβ expression
(Public Library of Science, 2009-6-22)BACKGROUND. Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). METHODS/PRINCIPAL ... -
Comparison of Proteomic and Transcriptomic Profiles in the Bronchial Airway Epithelium of Current and Never Smokers
(Public Libary of Science, 2009-4-9)BACKGROUND. Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the lung and airway, the impact of smoking on the airway epithelial proteome and its relationship to smoking-related ...
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