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  Redox-Sensitivity and Site-Specificity of S- and N- Denitrosation in Proteins 

  Jourd'heuil, Frances L.; Lowery, Anthony M.; Melton, Elaina M.; Mnaimneh, Sanie; Bryan, Nathan S.; Fernandez, Bernadette O.; Park, Joo-Ho; Ha, Chung-Eun; Bhagavan, Nadhipuram V.; Feelisch, Martin; Jourd'heuil, David (Public Library of Science, 2010-12-21)

  BACKGROUND. S-nitrosation - the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins - is a posttranslational modification involved in signal transduction and nitric oxide (NO) transport. Recent studies ...
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  The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia 

  Grenz, Almut; Osswald, Hartmut; Eckle, Tobias; Yang, Dan; Zhang, Hua; Tran, Zung Vu; Klingel, Karin; Ravid, Katya; Eltzschig, Holger K. (Public Library of Science, 2008-6-24)

  BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified ...
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  ω-3 Polyunsaturated Fatty Acids Prevent Pressure Overload-Induced Ventricular Dilation and Decrease in Mitochondrial Enzymes Despite no Change in Adiponectin 

  O'Shea, Karen M.; Chess, David J.; Khairallah, Ramzi J.; Hecker, Peter A.; Lei, Biao; Walsh, Kenneth; Des Rosiers, Christine; Stanley, William C. (BioMed Central, 2010-9-6)

  BACKGROUND Pathological left ventricular (LV) hypertrophy frequently progresses to dilated heart failure with suppressed mitochondrial oxidative capacity. Dietary marine ω-3 polyunsaturated fatty acids (ω-3 PUFA) up-regulate ...
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  Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice 

  Sanoudou, D.; Duka, A.; Drosatos, K.; Hayes, K. C.; Zannis, V. I. (Nature Publishing Group, 2009-12-01)

  We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment. Multilevel bioinformatical ...
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  Myogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophy 

  Peter, Angela K.; Ko, Christopher Y.; Kim, Michelle H.; Hsu, Nigel; Ouchi, Noriyuki; Rhie, Suhn; Izumiya, Yasuhiro; Zeng, Ling; Walsh, Kenneth; Crosbie, Rachelle H. (Oxford University Press, 2008-11-04)

  Duchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting. Here we show that myogenic ...
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  Metabolic Profiling of the Human Response to a Glucose Challenge Reveals Distinct Axes of Insulin Sensitivity 

  Shaham, Oded; Wei, Ru; Wang, Thomas J.; Ricciardi, Catherine; Lewis, Gregory D.; Vasan, Ramachandran S.; Carr, Steven A.; Thadhani, Ravi; Gerszten, Robert E.; Mootha, Vamsi K. (Nature Publishing GroupMolecular Systems Biology, 2008-08-05)

  Glucose ingestion after an overnight fast triggers an insulin-dependent, homeostatic program that is altered in diabetes. The full spectrum of biochemical changes associated with this transition is currently unknown. We ...
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  Interpreting Metabolomic Profiles using Unbiased Pathway Models 

  Deo, Rahul C.; Hunter, Luke; Lewis, Gregory D.; Pare, Guillaume; Vasan, Ramachandran S.; Chasman, Daniel I.; Wang, Thomas J.; Gerszten, Robert E.; Roth, Frederick P. (Public Library of Science, 2010-2-26)

  Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...
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  Genome-Wide Association of Echocardiographic Dimensions, Brachial Artery Endothelial Function and Treadmill Exercise Responses in the Framingham Heart Study 

  Vasan, Ramachandran S.; Larson, Martin G.; Aragam, Jayashri; Wang, Thomas J.; Mitchell, Gary F.; Kathiresan, Sekar; Newton-Cheh, Christopher; Vita, Joseph A.; Keyes, Michelle J.; O'Donnell, Christopher J.; Levy, Daniel; Benjamin, Emelia J. (BioMed Central, 2007-9-19)

  BACKGROUND: Echocardiographic left ventricular (LV) measurements, exercise responses to standardized treadmill test (ETT) and brachial artery (BA) vascular function are heritable traits that are associated with cardiovascular ...
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  Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals 

  Lieb, Wolfgang; Sullivan, Lisa M.; Harris, Tamara B.; Roubenoff, Ronenn; Benjamin, Emelia J.; Levy, Daniel; Fox, Caroline S.; Wang, Thomas J.; Wilson, Peter W.; Kannel, William B.; Vasan, Ramachandran S. (American Diabetes Association, 2008-12-29)

  OBJECTIVE: Obesity predisposes individuals to congestive heart failure (CHF) and cardiovascular disease (CVD). Leptin regulates energy homeostasis, is elevated in obesity, and influences ventricular and vascular remodeling. ...
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  Activation of Adenosine A2B Receptors Enhances Ciliary Beat Frequency in Mouse Lateral Ventricle Ependymal Cells 

  Genzen, Jonathan R.; Yang, Dan; Ravid, Katya; Bordey, Angelique (BioMed Central, 2009-11-18)

  BACKGROUND: Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system. While ...

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