Arthritis Center/Rheumatology
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Boston University Arthritis Center is an internationally recognized center in research, patient care and education. The Center was established in 1983 to advance basic, clinical, and epidemiological research in rheumatology and to translate laboratory findings into new therapeutic strategies. The Center unifies extensive basic, translational and clinical research, medical education, and patient care. Arthritis Center faculty include faculty in general rheumatology, and also faculty within focused programs in Scleroderma, Vasculitis, and Clinical Epidemiology. Our multidisciplinary programs in scleroderma and vasculitis are highly integrated with experts in many specialties, including those in pulmonary/pulmonary hypertension. Clinical care is provided at the Boston Medical Center in state-of-the art out and in-patient facilities. The Center’s clinical research teams have been at the forefront of developing new approaches to study and test new treatments for scleroderma, osteoarthritis, vasculitis and other autoimmune disorders. Visit the Arthritis Center's website for more information.
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Results of a Phase-I/II Randomized, Masked, Placebo-Controlled Trial of Recombinant Human Interleukin-11 (rhIL-11) in the Treatment of Subjects with Active Rheumatoid Arthritis
(BioMed Central, 2001-4-10)Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production. In animal models ... -
Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) Is related to a diminished CD69 and TGFβ expression
(Public Library of Science, 2009-6-22)BACKGROUND. Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). METHODS/PRINCIPAL ... -
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFβ and IFNϒ distinguishes SSc phenotypes
(Public Library of Science, 2009-6-17)BACKGROUND. Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. METHODOLOGY AND PRINCIPAL ... -
Autocrine Transforming Growth Factor β Signaling Regulates Extracellular Signal-regulated Kinase 1/2 Phosphorylation via Modulation of Protein Phosphatase 2A Expression in Scleroderma Fibroblasts
(BioMed Central, 2010-12-06)BACKGROUND. During scleroderma (SSc) pathogenesis, fibroblasts acquire an activated phenotype characterized by enhanced production of extracellular matrix (ECM) and constitutive activation of several major signaling pathways ... -
Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury
(Public Library of Science, 2010-8-17)BACKGROUND. Pulmonary arterial hypertension (PAH) is a common complication for individuals with limited systemic sclerosis (lSSc). The identification and characterization of biomarkers for lSSc-PAH should lead to less ...