Center for Biodynamics
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URI: http://hdl.handle.net/2144/2709
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The Mechanism of Abrupt Transition between Theta and Hyper-Excitable Spiking Activity in Medial Entorhinal Cortex Layer II Stellate Cells
(Public Library of Science, 2010-11-4)Recent studies have shown that stellate cells (SCs) of the medial entorhinal cortex become hyper-excitable in animal models of temporal lobe epilepsy. These studies have also demonstrated the existence of recurrent connections ... -
Representation of Time-Varying Stimuli by a Network Exhibiting Oscillations on a Faster Time Scale
(Public Library of Science, 2009-5-1)Sensory processing is associated with gamma frequency oscillations (30–80 Hz) in sensory cortices. This raises the question whether gamma oscillations can be directly involved in the representation of time-varying stimuli, ... -
Gyrase Inhibitors Induce an Oxidative Damage Cellular Death Pathway in Escherichia Coli
(2007-03-13)Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap the gyrase ... -
Size Matters: Network Inference Tackles the Genome Scale
(2007-02-13) -
Cortical Gamma Rhythms Modulate NMDAR-Mediated Spike Timing Dependent Plasticity in a Biophysical Model
(Public Library of Science, 2009-12-11)Spike timing dependent plasticity (STDP) has been observed experimentally in vitro and is a widely studied neural algorithm for synaptic modification. While the functional role of STDP has been investigated extensively, ... -
A Network Biology Approach to Prostate Cancer
(2007-02-13)There is a need to identify genetic mediators of solid-tumor cancers, such as prostate cancer, where invasion and distant metastases determine the clinical outcome of the disease. Whole-genome expression profiling offers ... -
Tuning and Controlling Gene Expression Noise in Synthetic Gene Networks
(Oxford University Press, 2010-03-08)Synthetic gene networks can be used to control gene expression and cellular phenotypes in a variety of applications. In many instances, however, such networks can behave unreliably due to gene expression noise. Accordingly, ... -
Rhythm Generation through Period Concatenation in Rat Somatosensory Cortex
(Public Library of Science, 2008-9-5)Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in ...
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