Center for Human Genetics

 
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URI: http://hdl.handle.net/2144/2728

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  • RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans 

    Sebastiani, Paola; Montano, Monty; Puca, Annibale; Solovieff, Nadia; Kojima, Toshio; Wang, Meng C.; Melista, Efthymia; Meltzer, Micah; Fischer, Sylvia E. J.; Andersen, Stacy; Hartley, Stephen H.; Sedgewick, Amanda; Arai, Yasumichi; Bergman, Aviv; Barzilai, Nir; Terry, Dellara F.; Riva, Alberto; Anselmi, Chiara Viviani; Malovini, Alberto; Kitamoto, Aya; Sawabe, Motoji; Arai, Tomio; Gondo, Yasuyuki; Steinberg, Martin H.; Hirose, Nobuyoshi; Atzmon, Gil; Ruvkun, Gary; Baldwin, Clinton T.; Perls, Thomas T. (Public Library of Science, 2009-12-14)
    BACKGROUND. The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein ...

  • Lack of Association between Angiotensin-Converting Enzyme and Dementia of the Alzheimer's Type in an Elderly Arab Population in Wadi Ara, Israel 

    Bowirrat, Abdalla; Cui, Jing; Waraska, Kristin; Friedland, Robert P.; Oscar-Berman, Marlene; Farrer, Lindsay A.; Korczyn, Amos; Baldwin, Clinton T. (Dove Medical Press, 2005)
    The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene ...

  • Performance of Random Forest When SNPs Are in Linkage Disequilibrium 

    Meng, Yan A.; Yu, Yi; Cupples, L. Adrienne; Farrer, Lindsay A.; Lunetta, Kathryn L. (BioMed Central, 2009-3-5)
    BACKGROUND. Single nucleotide polymorphisms (SNPs) may be correlated due to linkage disequilibrium (LD). Association studies look for both direct and indirect associations with disease loci. In a Random Forest (RF) analysis, ...