Department of Pathology and Laboratory Medicine
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Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
(OXFORD UNIV PRESS, 2018-02-01)The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes ... -
The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer
(BioMed Central, 2010-3-8)INTRODUCTION. HJURP (Holliday Junction Recognition Protein) is a newly discovered gene reported to function at centromeres and to interact with CENPA. However its role in tumor development remains largely unknown. The goal ... -
Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth
(Public Library of Science, 2009-10-6)An actin regulatory protein unexpectedly also controls microtubule polymerization during the formation and maintenance of cellular outgrowths in neurons. Capping protein (CP) is a heterodimer that regulates actin assembly ... -
Telomeric DNA Induces Apoptosis and Senescence of Human Breast Carcinoma Cells
(BioMed Central, 2007-1-26)INTRODUCTION. Cancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and delays carcinogenesis after carcinogen exposure, ... -
COMBREX: A Project to Accelerate the Functional Annotation of Prokaryotic Genomes
(2010-11-20)COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists ... -
IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis
(Public Library of Science, 2008-12-3)BACKGROUND. Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer and age-related macular degeneration. Although ... -
Tri-Nucleotide Receptors Play a Critical Role in Epithelial Cell Wound Repair
(Springer Netherlands, 2005-7-29)The cornea plays a major role in the refraction of light to the retina. Therefore, the integrity and transparency of the corneal epithelium are critical to vision. Following injury, a combination of rapid signal transduction ... -
Loss of AND-34/BCAR3 Expression in Mice Results in Rupture of the Adult Lens
(Molecular Vision, 2009-4-03)PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor ... -
Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease
(Public Library of Science, 2009-8-12)DNA methylation [1], [2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease ... -
Microarray Gene Expression Profiling and Analysis in Renal Cell Carcinoma
(BioMed Central, 2004-6-22)BACKGROUND. Renal cell carcinoma (RCC) is the most common cancer in adult kidney. The accuracy of current diagnosis and prognosis of the disease and the effectiveness of the treatment for the disease are limited by the ...