Department of Physiology and Biophysics
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Functional remodeling of the contractile smooth muscle cell cortex, a provocative concept, supported by direct visualization of cortical remodeling
(MDPI AG, 2022-04-26)Considerable controversy has surrounded the functional anatomy of the cytoskeleton of the contractile vascular smooth muscle cell. Recent studies have suggested a dynamic nature of the cortical cytoskeleton of these cells, ... -
Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing
(2009-8)The universally conserved eukaryotic initiation factor (eIF), eIF1A, plays multiple roles throughout initiation: it stimulates eIF2/GTP/Met-tRNAiMet attachment to 40S ribosomal subunits, scanning, start codon selection and ... -
Metabolic Constraints on the Recovery of Sensitivity after Visual Pigment Bleaching in Retinal Rods
(The Rockefeller University Press, 2009-08-17)The shutoff of active intermediates in the phototransduction cascade and the reconstitution of the visual pigment play key roles in the recovery of sensitivity after the exposure to bright light in both rod and cone ... -
High Density Lipoproteins-Based Therapies for Cardiovascular Disease
(Medknow Publications, 2010-07)Atherosclerosis is the leading cause of death in developed countries. High density lipoproteins (HDL) cholesterol level correlates inversely with the risk of cardiovascular diseases. Thus, HDL has obtained lots of interest ... -
The 9-Methyl Group of Retinal Is Essential for Rapid Meta II Decay and Phototransduction Quenching in Red Cones
(The Rockefeller University Press, 2009-07-27)Cone photoreceptors of the vertebrate retina terminate their response to light much faster than rod photoreceptors. However, the molecular mechanisms underlying this rapid response termination in cones are poorly understood. ... -
Molecular Model of the Microvillar Cytoskeleton and Organization of the Brush Border
(Public Library of Science, 2010-2-24)BACKGROUND. Brush border microvilli are ~1-µm long finger-like projections emanating from the apical surfaces of certain, specialized absorptive epithelial cells. A highly symmetric hexagonal array of thousands of these ... -
Crystal structure of the P Pilus rod subunit PapA
(Public Library of SciencePathogens, 2007-5-18)P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC ... -
Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth
(Public Library of Science, 2009-10-6)An actin regulatory protein unexpectedly also controls microtubule polymerization during the formation and maintenance of cellular outgrowths in neurons. Capping protein (CP) is a heterodimer that regulates actin assembly ... -
Giardia Cyst Wall Protein 1 Is a Lectin That Binds to Curled Fibrils of the GalNAc Homopolymer
(Public Library of Science, 2010-8-19)The infectious and diagnostic stage of Giardia lamblia (also known as G. intestinalis or G. duodenalis) is the cyst. The Giardia cyst wall contains fibrils of a unique β-1,3-linked N-acetylgalactosamine (GalNAc) homopolymer ... -
Mechanisms in Bradykinin Stimulated Arachidonate Release and Synthesis of Prostaglandin and Platelet Activating Factor
(Hindawi Publishing Corporation, 1982)Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). ...