Department of Ophthalmology
Browse by:
Recently Added
-
A Computational Approach for Deciphering the Organization of Glycosaminoglycans
(Public Library of Science, 2010-2-23)BACKGROUND. Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes. Glycosaminoglycans are a class of glycans that bind and regulate the function of a wide ... -
IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis
(Public Library of Science, 2008-12-3)BACKGROUND. Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer and age-related macular degeneration. Although ... -
Tri-Nucleotide Receptors Play a Critical Role in Epithelial Cell Wound Repair
(Springer Netherlands, 2005-7-29)The cornea plays a major role in the refraction of light to the retina. Therefore, the integrity and transparency of the corneal epithelium are critical to vision. Following injury, a combination of rapid signal transduction ... -
FOXO1 Plays an Essential Role in Apoptosis of Retinal Pericytes
(Molecular Vision, 2010-3-10)PURPOSE. An early and significant event in diabetic retinopathy is the loss of retinal microvascular pericytes. Studies were performed to investigate pathways through which an advanced glycation endproduct and tumor necrosis ... -
FOXO1 Plays an Important Role in Enhanced Microvascular Cell Apoptosis and Microvascular Cell Loss in Type 1 and Type 2 Diabetic Rats
(American Diabetes Association, 2009-1-23)OBJECTIVE: To investigate early events leading to microvascular cell loss in diabetic retinopathy. RESEARCH DESIGN AND METHODS: FOXO1 was tested in vivo by DNA binding activity and by nuclear translocation in microvascular ...
RSS 1.0