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  Ethanol exposure perturbs sea urchin development and disrupts developmental timing 

  Rodríguez-Sastre, Nahomie; Shapiro, Nicholas; Hawkins, Dakota Y.; Lion, Alexandra T.; Peyreau, Monique; Correa, Andrea E.; Dionne, Kristin; Bradham, Cynthia A. (2022-07-10)

  Ethanol is a known vertebrate teratogen that causes craniofacial defects as a component of fetal alcohol syndrome (FAS). Our results show that sea urchin embryos treated with ethanol similarly show broad skeletal patterning ...
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  Polychrome labeling reveals skeletal triradiate and elongation dynamics and abnormalities in patterning cue-perturbed embryos 

  Descoteaux, Abigail E.; Zuch, Daniel T.; Bradham, Cynthia A. (2022-12-14)
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  ICAT: a novel algorithm to robustly identify cell states following perturbations in single cell transcriptomes 

  Hawkins, Dakota Y.; Zuch, Daniel T.; Huth, James; Rodriguez-Sastre, Nahomie; McCutcheon, Kelley R.; Glick, Abigail; Lion, Alexandra T.; Thomas, Christopher F.; Descoteaux, Abigail E.; Johnson, W. Evan; Bradham, Cynthia A. (2022-05-29)
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  The developmental transcriptome for Lytechinus variegatus exhibits temporally punctuated gene expression changes 

  Hogan, John D.; Keenan, Jessica L.; Luo, Lingqi; Ibn-Salem, Jonas; Lamba, Arjun; Schatzberg, Daphne; Piacentino, Michael L.; Zuch, Daniel T.; Core, Amanda B.; Blumberg, Carolyn; Timmermann, Bernd; Grau, José Horacio; Speranza, Emily; Andrade-Navarro, Miguel A.; Irie, Naoki; Poustka, Albert J.; Bradham, Cynthia A. (Elsevier BV, 2020-04-15)

  Embryonic development is arguably the most complex process an organism undergoes during its lifetime, and understanding this complexity is best approached with a systems-level perspective. The sea urchin has become a highly ...
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  Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression 

  Thomas, Christopher F.; Hawkins, Dakota Y.; Skidanova, Viktoriya; Marrujo, Simone R.; Gibson, Janay; Ye, Ziqing; Bradham, Cynthia A. (2022-11-18)
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  Derivedness index for estimating degree of phenotypic evolution of embryos: a study of comparative transcriptomic analyses of chordates and echinoderms 

  Leong, Jason Cheok Kuan; Li, Yongxin; Uesaka, Masahiro; Uchida, Yui; Omori, Akihito; Hao, Meng; Wan, Wenting; Dong, Yang; Ren, Yandong; Zhang, Si; Zeng, Tao; Wang, Fayou; Chen, Luonan; Wessel, Gary; Livingston, Brian T.; Bradham, Cynthia A.; Wang, Wen; Irie, Naoki (Frontiers Media SA, 2021)

  Species retaining ancestral features, such as species called living fossils, are often regarded as less derived than their sister groups, but such discussions are usually based on qualitative enumeration of conserved traits. ...
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  Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses 

  Besnard, Antoine; Gao, Yuan; Kim, Michael TaeWoo; Twarkowski, Hannah; Reed, Alexander Keith; Langberg, Tomer; Feng, Wendy; Xu, Xiangmin; Saur, Dieter; Zweifel, Larry S.; Davison, Ian G.; Sahay, Amar (NATURE PUBLISHING GROUP, 2019-03-01)

  Adaptive fear responses to external threats rely upon efficient relay of computations underlying contextual encoding to subcortical circuits. Brain-wide analysis of highly coactivated ensembles following contextual fear ...
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  The Bruce effect: representational stability and memory formation in the accessory olfactory bulb of the female mouse 

  Yoles-Frenkel, Michal; Shea, Stephen D.; Davison, Ian G.; Ben-Shaul, Yoram (Elsevier BV, 2022-08-23)

  In the Bruce effect, a mated female mouse becomes resistant to the pregnancy-blocking effect of the stud. Various lines of evidence suggest that this form of behavioral imprinting results from reduced sensitivity of the ...
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  Rapid changes in synaptic strength after mild traumatic brain injury 

  Witkowski, Ellen D.; Gao, Yuan; Gavsyuk, Alexander F.; Maor, Ido; DeWalt, Gloria J.; Eldred, William D.; Mizrahi, Adi; Davison, Ian G. (Frontiers Media SA, 2019)

  Traumatic brain injury (TBI) affects millions of Americans annually, but effective treatments remain inadequate due to our poor understanding of how injury impacts neural function. Data are particularly limited for mild, ...
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  Understanding the roles of glia and circulating leukocytes in neurodegenerative diseases 

  Tay, Tuan Leng; Locatelli, Giuseppe; Constantin, Gabriela; Yong, V. Wee (Frontiers Media SA, 2022-05-03)

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